| Catalog Number | Product | Size | Price | |
|---|---|---|---|---|
| C3031 | FLAG-Cynomolgus CCR8-CHO-K1 Stable Cell Line | 2 vials | $5950 | Order |
| Catalog Number | C3031 |
|---|---|
| Cell Line Name | FLAG-Cynomolgus CCR8-CHO-K1 Stable Cell Line |
| Accession Number | NP_001274549.1 |
| Host Cell | Adherent CHO-K1 |
| Quantity | Two vials of frozen cells (2x106 per vial) |
| Culture Medium | DMEM with 10% FBS, 4 µg/ml puromycin |
| Freezing Medium | 90% FBS and 10% DMSO |
| Storage | Liquid nitrogen upon receipt |
| Product Datasheet: | Download PDF |
Detection of cyCCR8 expression in CHOK1-Flag-cyCCR8 cells using an anti-cyCCR8 monoclonal antibody followed by staining with PE-anti human antibody. The cells that are stained only with PE-anti-human IgG antibody are used as a negative control
CR8, also known as CY6, TER1, CCR-8, CKRL1, CDw198, CMKBR8, GPRCY6, CMKBRL2, CC-CKR-8, is a C-C motif chemokine receptor of the G proteincoupled receptor (GPCR) family and is expressed on the cell surface of regulatory T cells (Tregs). Activation of CCR8 by binding of C-C motif chemokine ligands CCL1, CCL8, CCL16 and CCL18 can lead to activating the functionality of Tregs in immune response suppression. CCR8 expression is upregulated and highly expressed in many cancers such as bladder, breast, and colorectal cancer increasing migration and invasion activity and antiapoptosis in Tregs. This activity shows an association between CCR8 expression and cancer progression making CCR8 a potential target molecule for cancer immunotherapy.
Saito M, Suzuki H, Tanaka T, Asano T, Kaneko MK, Kato Y. Development of an Anti-Mouse CCR8 Monoclonal Antibody (C8Mab-1) for Flow Cytometry and Immunocytochemistry. Monoclon Antib Immunodiagn Immunother. 2022.