Human CLDN18.1-DYK-CHO Stable Cell Pool

Catalog Number Product Size Price
C1002 Human CLDN18.1-DYK-CHO Stable Cell Pool 2 vials $5500 Order

Product Description:

Name:                                                   CHO suspension cell pool expressing full-length human CLDN18.1 receptor

Gene Synonyms:                                CLDN18.1

Gene Sequence:                                 Codon optimized from Accession# NP_057453. A DYKDDDK tag is inserted into a position between V144 and T145.

Protein Structure:                               Four span-transmembrane receptor

Host Cell:                                             Suspension CHO

Quantity:                                              Two vials of frozen cells (20x10E6 per vial)

Stability:                                               >10 passages

Freeze Media:                                      Culture media with 10% DMSO

Storage:                                                Liquid nitrogen immediately upon arrival

Mycoplasma Test:                              Negative

Applications:                                       Antibody binding assays, IHC/Western blot analysis, or use as cell immunogen

Product Datasheet/Protocols:      Download PDF

Background Information:

Claudin-18 (CLDN18) is a member of a large family of four-span transmembrane proteins called Claudins. These proteins are the essential components of the mammalian tight junctions (TJs) in epithelial cells. Claudin-18 has two splice variants, 18.1 and 18.2. While CLDN18.1 is specifically expressed in the lung tissue, CLDN18.2 expression in normal tissue is more restricted and is only detected in small patches of stomach mucosal. CLDN18.2 expression is elevated in many types of epithelial cancers including stomach, esophagus, pancreatic and ovarian cancers. The expression of CLDN18.2 is not only detected in primary tumors, but also in the metastatic sites. Therefore, CLDN18.2 is an ideal target for monoclonal antibody-based cancer therapies.

Representative Data:

Detection of human CLDN18.1 expression on CHO-S/Human CLDN18.1 cells using a mouse monoclonal antibody specific for the DYKDDDK peptide.




  1. Tureci O. et al. (2011) Claudin-18 Gene Structure, Regulation, and Expression is Evolutionary Conserved in Mammals. Gene, 481(2):83.
  2. Sahin, U. et al. (2008) Claudin-18 Splice Variant 2 is a Pan-Cancer Target Suitable for Therapeutic Antibody Development. Clin. Cancer Res. 14(23):7624.
  3. Niimi, T. et al. (2001) Claudin-18, A Novel Downstream Target Gene for the T/ENB/NKX2.1 Homerodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms Through Alternative Splicing. Mol. Cell. Biol. 21(21):7380.