|C1002||Human CLDN18.1-DYK-CHO Stable Cell Pool||2 vials||$6000||Order|
Name: CHO suspension cell pool expressing full-length human CLDN18.1 receptor
Gene Synonyms: CLDN18.1
Gene Sequence: Codon optimized from Accession# NP_057453. A DYKDDDK tag is inserted into a position between V144 and T145.
Protein Structure: Four span-transmembrane receptor
Host Cell: Suspension CHO
Quantity: Two vials of frozen cells (20x10E6 per vial)
Stability: >10 passages
Freeze Media: Culture media with 10% DMSO
Storage: Liquid nitrogen immediately upon arrival
Mycoplasma Test: Negative
Applications: Antibody binding assays, IHC/Western blot analysis, or use as cell immunogen
Product Datasheet/Protocols: Download PDF
Claudin-18 (CLDN18) is a member of a large family of four-span transmembrane proteins called Claudins. These proteins are the essential components of the mammalian tight junctions (TJs) in epithelial cells. Claudin-18 has two splice variants, 18.1 and 18.2. While CLDN18.1 is specifically expressed in the lung tissue, CLDN18.2 expression in normal tissue is more restricted and is only detected in small patches of stomach mucosal. CLDN18.2 expression is elevated in many types of epithelial cancers including stomach, esophagus, pancreatic and ovarian cancers. The expression of CLDN18.2 is not only detected in primary tumors, but also in the metastatic sites. Therefore, CLDN18.2 is an ideal target for monoclonal antibody-based cancer therapies.