Human CLDN18.2-CHO-S Stable Cell Pool

Catalog Number Product Size Price
C1001 Human CLDN18.2-CHO-S Stable Cell Pool 2 vials $6000 Order

Background Information

Claudin-18 (CLDN18) is a member of a large family of four-span transmembrane proteins called Claudins. These proteins are the essential components of the mammalian tight junctions (TJs) in epithelial cells. Claudin18 has two splice variants, 18.1 and 18.2. While CLDN18.1 is specifically expressed in the lung tissue, CLDN18.2 expression in normal tissue is more restricted and is only detected in small patches of stomach mucosal. CLDN18.2 expression is elevated in many types of epithelial cancers including stomach, esophagus, pancreatic and ovarian cancers. The expression of CLDN18.2 is not only detected in primary tumors, but also in the metastatic sites. Therefore, CLDN18.2 is an ideal target for monoclonal antibody-based cancer therapies.

Product Description

Catalog Number C1001
Cell Line Name Human CLDN18.2-CHO stable cells; CHO suspension cell pool expressing full-length human CLDN18.2 receptor
Gene Synonyms CLDN18.2
Gene Sequence Codon optimized from NP_001001026 (Met1-Val261)
Protein Structure Four span-transmembrane receptor
Host Cell Suspension CHO
Quantity Two vials of frozen cells (20x106 per vial)
Stability >10 passages
Freeze Media Culture medium with 10% DMSO
Storage Liquid nitrogen
Culture Media 50% CD-CHO (Gibco # 10743-029), 50% Ex-Cell CHO 5 Media (Sigma#C0363), supplemented with 8 mM L-Glutamine, 1x HT (Gibco #11067030), 1x PenicillinStreptomycin, and 10 µg/ml Puromycin.
Mycoplasma Test Negative
Applications Antibody binding assays, IHC/Western blot analysis, or use as cell immunogen
Product Datasheet: Download PDF

Representative Data

Detection of human CLDN18.2 expression on human CLDN18.2-CHO Stable cells using a monoclonal antibody specific for human CLDN18.2


Tureci O. et al. (2011) “Claudin-18 Gene Structure, Regulation, and Expression is Evolutionary Conserved in Mammals”. Gene, 481(2):83.

Sahin, U. et al. (2008) “Claudin-18 Splice Variant 2 is a Pan-Cancer Target Suitable for Therapeutic Antibody Development”. Clin. Cancer Res. 14(23):7624.

Niimi, T. et al. (2001) “Claudin-18, A Novel Downstream Target Gene for the T/ENB/NKX2.1 Homerodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms Through Alternative Splicing”. Mol. Cell. Biol. 21(21):7380.