Recombinant Human IgSF11 ECD-Fc


Catalog Number Product Size Price
P1002-B Recombinant Human IgSF11 ECD-Fc Bulk Inquire
P1002-100 Recombinant Human IgSF11 ECD-Fc 100 µg $249 Order
P1002-200 Recombinant Human IgSF11 ECD-Fc 200 µg $379 Order

Product Specifications


Source:

Human IgSF11 (Accession# AAH34411.1) extracellular domain (Ser21-Arg237) fused with human IgG1 Fc produced from CHO cells. 


Structure:Disulfide-linked homodimer
Predicted N-terminal:Ser 21
Predicted Molecular Weight:48.9 kDa (monomer)
Apparent Molecular Weight on SDS-PAGE:55.0 kDa, reducing conditions
Formulation:0.22 µm filtered protein solution in PBS
Storage:< -20°C
Estimated Purity:>95% as determined by SDS-PAGE
Protein Endotoxin Level:Not measured
Protein Aggregation:Insignificant on SDS-PAGE


Product Description


Application:Biochemical analysis
Product Description:IgSF11 is a member of the immunoglobulin superfamily. It has a 23-residue signal peptide, 3 potential extracellular N-linked glycosylation sites, an extracellular V-type Ig-like domain, an extracellular C2-type Ig-like domain, and a 170-residue cytoplasmic tail with a C-terminal PDZ-interacting motif (1). IgSF11 functions as an adhesion molecule with homophilic molecular interaction (2). It is a 52-kD glycoprotein that is expressed highest in testis, and lower in brain, kidney, and adrenal gland. Within brain, expression in the corpus callosum was comparable to that in testis (1). It is suggested to be a diagnostic and/or clinical target for gastric cancer (3). 
Other Names:VSIG3, BT-IgSF, CT119
References:
  1. Suzu, S. et al. (2002) Biochem Biophys. Res. Commun. 265:1215.
  2. Harada, H. et al. (2005) J. Cell. Physiol. 204:919.
  3. Katoh, M. and Katoh, M. (2003) Int. J. Oncol.. 23:525.
Product Datasheet:Download PDF


Data


SDS-PAGE Analysis


10 µg/lane of human IgSF11 ECD-human Fc was resolved on SDS-PAGE gel in non-reducing (NR) and reducing (R) conditions and visualized by coomassie blue staining.