|P1003-100||Recombinant Human CD33 Fc Chimera Protein||100 µg||$229||Order|
|P1003-200||Recombinant Human CD33 Fc Chimera Protein||200 µg||$439||Order|
|P1003-B||Recombinant Human CD33 Fc Chimera Protein||Bulk||Inquire|
|Source:||Human CD33 (Accession# NP_AAH28152.1) extracellular domain (Met 17 – Val 258) fused with human IgG1 produced from HEK293 cells.
|Predicted N-terminal:||Met 17|
|Predicted Molecular Weight:||52.8 kDa, reducing conditions|
|Apparent Molecular Weight on SDS-PAGE:||70 kDa, reducing conditions|
|Formulation:||0.22 µm filtered protein solution in PBS|
|Estimated Purity:||>95% as determined by SDS-PAGE|
|Protein Endotoxin Level:||Not measured|
|Protein Aggregation:||<10% as determined by SDS-PAGE|
|Application:||Bioassay (biochemical assay)|
|Product Description:||CD33 (cluster of differentiation 33) is a member of the immunoglobulin superfamily. It is a myeloid-specific member of the sialic acid-binding immunoglobulin-related lectin family which also includes CD22, sialoadhesin, myelin-associated glycoprotein, and siglecs 5, 7, and 8. Human CD33 is a 67 kDa transmembrane cell surface glycoprotein receptor with only one V-set and one C2-set Ig-like domains (1). The extracellular domain of CD33 binds alpha-2,3-linked sialic acid residues in N- and O-glycans on the cell surface (2). It can mediate sialic acid-dependent cell interactions as a recombinant protein (3). Studies have shown that in the presence of pervanadate, a phosphatase inhibitor, CD33 is tyrosine-phosphorylated and recruits SHP-1 and SHP-2 phosphatases, suggesting that CD33 functions as an inhibitory receptor (4).|
|Other Names:||Siglec-3, FLJ00391, P67|
|Product Datasheet:||Download PDF|
10 µg/lane of human CD33 Fc Chimera was resolved on SDS-PAGE gel in non-reducing (NR) and reducing (R) conditions and visualized by Coomassie Blue staining.