|C3041||CynoHER2-CT26 Stable Cell Line||2 vials||$2000||Order|
|Cell Line Name||CT26 stable cell line expressing receptor protein tyrosine kinase erbB-2 (HER2) from cynomolgus monkey (CynoHER2-CT26)|
|Host Cell||CT26, mouse colon carcinoma cells|
|Quantity||Two vials of frozen cells (2x106 per vial)|
|Culture Medium||RPMI with 10% FBS, 20 µg/ml puromycin|
|Freezing Medium||90% FBS and 10% DMSO|
|Storage||Liquid nitrogen upon receipt|
|Product Datasheet:||Download PDF|
Detection of CynoHER2 expression on CynoHER2-CT26 stable cells using Trastuzumab, an anti-human HER2 monoclonal antibody which cross-react with cynoHER2. (Cat.#A1019).
Her-2, also called Neu and ErbB2 (human epidermal growth factor receptor 2), is a type I membrane protein that is a member of the ErbB family of receptor tyrosine kinases. ErbB family members include EGFR, ErbB2 (Neu, Her-2), ErbB3 (Her-3), and ErbB4 (Her-4) and they serve as receptors for the epidermal growth factor (EGF) family of growth factors. Her-2 is widely expressed in epithelial cells and is over-expressed on a large population of breast cancer cells. Comparing to the other members of the ErbB family, Her-2 is unique in that it has no known ligands and it can heterodimerize with the other members of the ErbB family to form higher affinity signaling complexes. Mature human Her-2 consists of 1233 amino acids (aa) with a 630 aa extracellular domain, a 23 aa transmembrane region, and a 580 aa cytoplasmic domain. Her-2 may play a variety of roles in development and regulation of cell growth and differentiation (1-6).
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