Mouse CLDN 18.2 CHO-K1 Stable Cell Line

Catalog Number Product Size Price
C3012 Mouse CLDN 18.2 CHO-K1 Stable Cell Line 2 vials $6000 Order

Background Information

Claudin-18 (CLDN18) is a member of a large family of four-span transmembrane proteins called Claudins. These proteins are the essential components of the mammalian tight junctions (TJs) in epithelial cells. Claudin-18 has two splice variants, 18.1 and 18.2. While CLDN18.1 is specifically expressed in the lung tissue, CLDN18.2 expression in normal tissue is more restricted and is only detected in small patches of stomach mucosal. CLDN18.2 expression is elevated in many types of epithelial cancers including stomach, esophagus, pancreatic and ovarian cancers. The expression of CLDN18.2 is not only detected in primary tumors, but also in the metastatic sites. Therefore, CLDN18.2 is an ideal target for monoclonal antibody-based cancer therapies.

Product Specifications

Catalog Number C3012
Cell Line Name Mouse CLDN 18.2 CHO-K1 Stable Cell Line
Gene Sequence Full-length mouse CLDN18.2 (NP.001181850.1)
Host Cell CHO-K1 (Adherent cells)
Quantity Two vials of frozen cells (~1x106 per vial)
Culture Medium DMEM with 10% FBS and 4 µg/ml puromycin
Freezing Medium 90% FBS and 10% DMSO
Storage Liquid nitrogen upon receipt
Product Datasheet: Download PDF

Representative Data

Detection of mouse CLDN18.2 expression on mouse CLDN18.2-CHO-K1 cells using a monoclonal antibody specific for CLDN18.2 (Cat. #A1008)


Türeci O. et al. (2011) “Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals”. Gene, 481(2), p83-92.

Sahin U. et al. (2008) “Claudin-18 Splice Variant 2 Is a Pan-Cancer Target Suitable for Therapeutic Antibody Development”. Clin. Cancer Res. 14 (23) p7624-7634.

Niimi T. et al. (2001) “Claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Speci?c Isoforms through Alternative Splicing”. Mol. Cell. Biol. 21(21), p7380-7390.