Human CLDN18.2 CHO-K1 Stable Cell Line

Catalog Number Product Size Price
C3011 Human CLDN18.2 CHO-K1 Stable Cell Line 2 vials $6000 Order

Product Specifications

Catalog Number C3011
Cell Line Name Human CLDN 18.2 CHO-K1 Stable Cell Line
Accession Number NP_001001026 (Met1-Val261)
Host Cell CHO-K1 (Adherent cells)
Quantity Two vials of frozen cells (~1x106 per vial)
Culture Medium DMEM with 10% FBS and 4 µg/ml puromycin
Freezing Medium 90% FBS and 10% DMSO
Storage Liquid nitrogen
Product Datasheet: Download PDF

Representative Data

Detection of human CLDN18.2 expression on human CLDN18.2-CHO Stable cells using an anti-CLDN18.2 mAb (Accurus, Cat. #A1008), followed by staining with a PE-anti-human IgG antibody.

Background Information

Claudin-18 (CLDN18) is a member of a large family of four-span transmembrane proteins called Claudins. These proteins are the essential components of the mammalian tight junctions (TJs) in epithelial cells. Claudin-18 has two splice variants, 18.1 and 18.2. While CLDN18.1 is specifically expressed in the lung tissue, CLDN18.2 expression in normal tissue is more restricted and is only detected in small patches of stomach mucosal. CLDN18.2 expression is elevated in many types of epithelial cancers including stomach, esophagus, pancreatic and ovarian cancers. The expression of CLDN18.2 is not only detected in primary tumors, but also in the metastatic sites. Therefore, CLDN18.2 is an ideal target for monoclonal antibody-based cancer therapies.


Türeci O. et al. Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals. Gene, 481:83-92. 2011 

Sahin U. et al. Claudin-18 Splice Variant 2 Is a Pan-Cancer Target Suitable for Therapeutic Antibody Development. Clin. Cancer Res. 14:7624-7634. 2008.

Niimi T. et al. Claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing. Mol. Cell. Biol. 21:7380-7390. 2001