Human DDR1-CHO-K1 stable cell line

Catalog Number Product Size Price
C3030 Human DDR1-CHO-K1 stable cell line 2 vials $2300 Order

Background Information

DDR1 (discoidin domain receptor tyrosine kinase 1), also known as CD167, CAK, DDR, NEP, HGK2, PTK3, RTK6, TRKE, EDDR1, MCK10, NTRK4, and PTK3A,is a receptor tyrosine kinase (RTK) and belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyosteliumdiscoideum protein discoidin I in its extracellular domain. DDR1 consists of three regions (an extracellular ligand binding domain, a transmembrane domain, and an intracellular region containing a kinase domain), with its kinase activity induced by receptor-specific ligand binding. Collagen binding to DDR1 stimulates its autophosphorylation, activating kinase activity and signaling to downstream signaling pathways. DDR1 expression is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain and is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and brain. DDR1 plays a key role in the development and progression of breast and ovarian cancer and is a promising therapeutic target.

Product Specifications

Catalog Number C3030
Cell Line Name Human DDR1-CHO-K1 stable cell line
Gene Sequence Full-length human DDR1 (NM_001954.5)
Host Cell CHO-K1 (Adherent cells)
Quantity Two vials of frozen cells (~1x106 per vial)
Culture Medium DMEM with 10% FBS and 4 µg/ml puromycin
Freezing Medium 90% FBS and 10% DMSO
Storage Liquid nitrogen
Product Datasheet: Download PDF

Representative Data

Detection of human DDR1 expression on CHO-K1 cells using a mouse anti-human anti-DDR1 monoclonal antibody, followed by staining with a PE-anti-mouse IgG antibody. The cells that are stained only with PE-anti-mouse IgG antibody are used as a negative control.


Johnson, J. D., Edman, J. C., Rutter, W. J., Proc. Nat. Acad. Sci. 90: 5677-5681, 1993.

Chen, L., et al, Frontiers in Cell and Dev. Bio.747314, 2021.

Letinger, B.,Int Rev Cell Mol Biol., 310: 39-87, 2014.

Vogel, W., et al., Mol. Cell, 1: 13–23, 1997.