Recombinant Human DDR1-Fc Protein

Catalog Number Product Size Price
P1024-100 Recombinant Human DDR1-Fc Protein 100 µg $149 Order
P1024-200 Recombinant Human DDR1-Fc Protein 200 µg $199 Order
P1024-500 Recombinant Human DDR1-Fc Protein 500 µg $399 Order
P1024-Bulk Recombinant Human DDR1-Fc Protein Bulk Inquire

Product Specifications

Source: Human DDR1 (Accession#AQY76781) extracellular domain (Asp21-Ile418) fused with the Fc portion of human IgG1, produced from HEK293 cells.
Structure: Disulfide-linked homodimer
Predicted Molecular Weight: 70 kDa, at reducing conditions
Concentration: 1 mg/mL in sterile 1xPBS, pH 6.8
Storage: < -20°C or below
Estimated Purity: > >95% as determined by SDS-PAGE
Protein Aggregation: <5% as determined by SDS-PAGE

Product Description

Application: Biochemical analysis
Product Description: DDR1 (discoidin domain receptor tyrosine kinase 1), also known as CD167, CAK, DDR, NEP, HGK2, PTK3, RTK6, TRKE, EDDR1, MCK10, NTRK4, and PTK3A,is a receptor tyrosine kinase (RTK) and belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyosteliumdiscoideum protein discoidin I in its extracellular domain. DDR1 consists of three regions (an extracellular ligand binding domain, a transmembrane domain, and an intracellular region containing a kinase domain), with its kinase activity induced by receptor-specific ligand binding. Collagen binding to DDR1 stimulates its autophosphorylation, activating kinase activity and signaling to downstream signaling pathways. DDR1 expression is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain and is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and brain. DDR1 plays a key role in the development and progression of breast and ovarian cancer and is a promising therapeutic target.
  1. Johnson, J. D., Edman, J. C., Rutter, W. J., Proc. Nat. Acad. Sci. 90: 5677-5681, 1993.
  2. Chen, L., et al, Frontiers in Cell and Dev. Bio.volume 9, article #747314, 2021204:919.
  3. Letinger, B.,Int Rev Cell Mol Biol., 310: 39-87, 2014 23:525.
  4. Vogel, W., et al., Mol. Cell, 1: 13–23, 1997
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SDS-PAGE Analysis

20ug/lane of human DDR1Fc Chimera was resolved on SDS-PAGE gel in non-reducing (lane 2) and reducing (lane 3) conditions and visualized by CoomassieBlue staining.