| Catalog Number | Product | Size | Price | |
|---|---|---|---|---|
| C3103 | Human HER2-EMT6 Stable Cell Line | 2 vials | $6000 | Order |
| Catalog Number | C3103 |
|---|---|
| Cell Line Name | Human HER2-EMT6 stable cell line |
| Accession Number | NP_004439 |
| Host Cell | EMT6 |
| Quantity | Two vials of frozen cells (2x106 per vial) |
| Culture Medium | DMEM with 10% FBS, 2 µg/ml puromycin |
| Freezing Medium | 90% FBS and 10% DMSO |
| Storage | Liquid nitrogen |
| Product Datasheet: | Download PDF |
Detection of human HER2 expression on human HER2-EMT6 stable cells (A) and EMT6 stable cells (B) using anti-human-HER2 Ab (Trastuzumab) (Cat.#A1019).
Her-2, also called Neu and ErbB2 (human epidermal growth factor receptor 2), is a type I membrane protein that is a member of the ErbB family of receptor tyrosine kinases. ErbB family members include EGFR, ErbB2 (Neu, Her-2), ErbB3 (Her-3), and ErbB4 (Her-4) and they serve as receptors for the epidermal growth factor (EGF) family of growth factors. Her-2 is widely expressed in epithelial cells and is over-expressed on a large population of breast cancer cells. Comparing to the other members of the ErbB family, Her-2 is unique in that it has no known ligands and it can heterodimerize with the other members of the ErbB family to form higher affinity signaling complexes. Mature human Her-2 consists of 1233 amino acids (aa) with a 630 aa extracellular domain, a 23 aa transmembrane region, and a 580 aa cytoplasmic domain. Her-2 may play a variety of roles in development and regulation of cell growth and differentiation (1-6).
Ullrich, A. et al. Nature 309:418. 1984.
Graus-Porta, D. et al. EMBO J. 16:1647. 1997.Singh, A.B. and R.C. Harris Cell. Signal. 17:1183. 2005.Burgess, A.W. et al. Mol. Cell 12:541. 2003.Roskoski Jr., R. Biochem. Biophys. Res. Commun. 319:1. 2004.Lemmon, M.A. et al. EMBO J. 16:281. 1997.