Product Specifications

Representative Data

Detection of human CD37 expression on human CD37-CHO-K1 stable cells using a monoclonal antibody specific for human CD37 (Invitrogen #17-0379-41)

Background

CD37 is a member of the tetraspanin family which are involved in various cellular processes such as cell migration, adhesion, signal transduction, and immune responses. CD37 plays a critical role in regulating immune cell function, particularly in B cells, T cells, and dendritic cells. In B cells, it is involved in B cell maturation and signal transduction pathways that regulate antibody production, survival, and proliferation. In T cells and dendritic cells, CD37 is involved in antigen presentation and the immune synapse formation between T cells and antigen-presenting cells. CD37 expression is largely restricted to the hematopoietic system and is absent in non-hematopoietic tissues leading to its association in hematologic cancers such as non-Hodgkin Lymphoma and chronic lymphocytic leukemia where CD37 is abnormally highly expressed. Given its role in B-cell malignancies , CD37 has emerged as a promising therapeutic target giving way to the development of several therapeutic strategies targeting CD37.

References

Payandeh Z, Noori E, Khalesi B, Mard-Soltani M, Abdolalizadeh J, Khalili S. Anti-CD37 targeted immunotherapy of B-Cell malignancies. Biotechnol Lett. 40(11-12):1459-1466. 2018.

Bobrowicz M, Kubacz M, Slusarczyk A, Winiarska M. CD37 in B Cell Derived Tumors-More than Just a Docking Point for Monoclonal Antibodies. Int J Mol Sci. 21(24):9531. 2020.

Robak T, Robak P. Anti-CD37 antibodies for chronic lymphocytic leukemia. Expert Opin Biol Ther. 14(5):651-661. 2014.