| Catalog Number | Product | Size | Price | |
|---|---|---|---|---|
| C3033 | Human CCR8-HEK293 Stable Cell Line | 2 vials | $4950 | Order |
| Catalog Number | C3033 |
|---|---|
| Cell Line Name | Human CCR8-HEK293 Stable Cell Line |
| Accession Number | NP_005192.1 |
| Host Cell | Adherent HEK293 |
| Quantity | Two vials of frozen cells (2x106 per vial) |
| Culture Medium | DMEM with 10% FBS, 1 µg/ml puromycin |
| Freezing Medium | 90% FBS and 10% DMSO |
| Storage | Liquid nitrogen upon receipt |
| Product Datasheet: | Download PDF |
Detection of human CCR8 expression on human CCR8-CHO-K1 cells using a PE-anti-human CCR8 antibody
CR8, also known as CY6, TER1, CCR-8, CKRL1, CDw198, CMKBR8, GPRCY6, CMKBRL2, CC-CKR-8, is a C-C motif chemokine receptor of the G proteincoupled receptor (GPCR) family and is expressed on the cell surface of regulatory T cells (Tregs). Activation of CCR8 by binding of C-C motif chemokine ligands CCL1, CCL8, CCL16 and CCL18 can lead to activating the functionality of Tregs in immune response suppression. CCR8 expression is upregulated and highly expressed in many cancers such as bladder, breast, and colorectal cancer increasing migration and invasion activity and antiapoptosis in Tregs. This activity shows an association between CCR8 expression and cancer progression making CCR8 a potential target molecule for cancer immunotherapy.
Saito M, Suzuki H, Tanaka T, Asano T, Kaneko MK, Kato Y. Development of an Anti-Mouse CCR8 Monoclonal Antibody (C8Mab-1) for Flow Cytometry and Immunocytochemistry. Monoclon Antib Immunodiagn Immunother. 41(6):333-338. 2022.