ASSAN

Human CCR8-CHO-K1 Stable Cell Line


Catalog Number Product Size Price
C3032 Human CCR8-CHO-K1 Stable Cell Line 2 vials $5000 Order

Product Specifications


Catalog Number C3032
Cell Line Name Human CCR8-CHO-K1 Stable Cell Line
Accession Number NP_005192.1
Host Cell Adherent CHO-K1
Quantity Two vials of frozen cells (2x106 per vial)
Culture Medium DMEM with 10% FBS, 4 µg/ml puromycin
Freezing Medium 90% FBS and 10% DMSO
Storage Liquid nitrogen upon receipt
Product Datasheet: Download PDF

Representative Data


Detection of human CCR8 expression on human CCR8-CHO-K1 cells using a PE-anti-human CCR8 antibody


Background


CR8, also known as CY6, TER1, CCR-8, CKRL1, CDw198, CMKBR8, GPRCY6, CMKBRL2, CC-CKR-8, is a C-C motif chemokine receptor of the G proteincoupled receptor (GPCR) family and is expressed on the cell surface of regulatory T cells (Tregs). Activation of CCR8 by binding of C-C motif chemokine ligands CCL1, CCL8, CCL16 and CCL18 can lead to activating the functionality of Tregs in immune response suppression. CCR8 expression is upregulated and highly expressed in many cancers such as bladder, breast, and colorectal cancer increasing migration and invasion activity and antiapoptosis in Tregs. This activity shows an association between CCR8 expression and cancer progression making CCR8 a potential target molecule for cancer immunotherapy.

References

Saito M, Suzuki H, Tanaka T, Asano T, Kaneko MK, Kato Y. Development of an Anti-Mouse CCR8 Monoclonal Antibody (C8Mab-1) for Flow Cytometry and Immunocytochemistry. Monoclon Antib Immunodiagn Immunother. 2022.