Product Specifications

Representative Data

Detection of human CSF-1R expression on human CSF-1R-CHO-K1 stable cells using a monoclonal antibody specific for human CSF-1R (Accurus, Cat.#A1026), followed by staining with PE-anti human IgG antibody.

Background

CSF1R (colony-stimulating factor 1 receptor, M-CSF receptor) is a transmembrane receptor protein, which belongs to the class III subfamily of receptor tyrosine kinases (RTKs) and is involved in several important cellular functions such as proliferation, differentiation, and survival of mononuclear phagocytes including macrophages and microglia. The ligands for CSF1R are colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34), which are cytokines secreted by various cells such as fibroblasts, endothelial cells, and stromal cells. Upon binding to its ligands, CSF1R undergoes dimerization and autophosphorylation, leading to the activation of downstream signaling pathways such as PI3K-AKT and MAPK-ERK. CSF1R is highly expressed in mononuclear phagocytes including macrophages and microglia. CSF1R is also expressed in some cancers such as breast cancer, ovarian cancer, and glioblastoma, where it plays a crucial role in promoting tumor growth, invasion, and metastasis. Inhibition of CSF1R signaling has shown promising results in preclinical studies as a therapeutic strategy for cancer treatment.

References

Stanley ER, Chitu V. CSF-1 receptor signaling in myeloid cells. Cold Spring HarbPerspect Biol. 6:a021857. 2014.

Lin H, et al. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science. 320: 807–11.2008.

Ries CH, et al. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell. 25:846-859. 2014.

Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 8:533-544. 2008.