Catalog Number | Product | Size | Price | |
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C3044 | Human ENPP1-CHO-S Stable Cell Line | 2 vials | $3950 | Order |
Catalog Number | C3044 |
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Cell Line Name | Human ENPP1-CHO-S Stable Cell Line |
Accession Number | NP_006199.2 |
Host Cell | Adherent CHO-K1 |
Quantity | Two vials of frozen cells (5x106 per vial) |
Culture Medium | CD-Opti-CHO with 4 µg/ml puromycin |
Freezing Medium | 90% FBS and 10% DMSO |
Storage | Liquid nitrogen upon receipt |
Product Datasheet: | Download PDF |
Detection of human ENPP1 expression on human ENPP1-CHO-S stable cells using a monoclonal antibody specific for human ENPP1 (Accurus #A1022)
Human ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1) is a membrane-bound glycoprotein that belongs to the family of ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) enzymes. ENPP1 is involved in a variety of physiological processes including bone mineralization, insulin signaling, and inflammation and is expressed in many tissues including bone, liver, adipose tissue, and cartilage. ENPP1 has both pyrophosphatase and phosphodiesterase activities and it plays a crucial role in regulating the levels of extracellular pyrophosphate, a mineralization inhibitor, in tissues such as bone and cartilage. It also serves as an inhibitor of insulin signaling, leading to insulin resistance in adipose tissue and skeletal muscle. In addition, ENPP1 has been implicated in various cellular processes such as cell adhesion, inflammation, and matrix calcification. ENPP1 has been found to be up regulated in various types of cancer, including breast, prostate, and colon cancer. Increased ENPP1 expression has been associated with cancer cell proliferation, migration, and invasion. This suggests that ENPP1 may play a role in cancer progression and metastasis. Given its link to a number of human diseases and cancers, there has been considerable interest in developing drugs that can modulate ENPP1 activity as a potential therapeutic strategy.
Roberts F, Zhu D, Farquharson C, Macrae VE. ENPP1 in the Regulation of Mineralization and Beyond. Trends Biochem Sci. 44(7):616-628. 2019.
Bacci S, De Cosmo S, Prudente S, Trischitta V. ENPP1 gene, insulin resistance and related clinical outcomes. Curr Opin Clin Nutr Metab Care. 10(4):403-9. 2007.
Li J, Duran MA, Dhanota N, Chatila WK, Bettigole SE, Kwon J, Sriram RK, Humphries MP, Salto-Tellez M, James JA, Hanna MG, Melms JC, Vallabhaneni S, Litchfield K, Usaite I, Biswas D, Bareja R, Li HW, Martin ML, Dorsaint P, Cavallo JA, Li P, Pauli C, Gottesdiener L, DiPardo BJ, Hollmann TJ, Merghoub T, Wen HY, Reis-Filho JS, Riaz N, Su SM, Kalbasi A, Vasan N, Powell SN, Wolchok JD, Elemento O, Swanton C, Shoushtari AN, Parkes EE, Izar B, Bakhoum SF. Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis. Cancer Discov. 11(5):1212-1227. 2021